Recombinant Human Haptoglobin Protein

重组人Haptoglobin蛋白 | 重组人结合珠蛋白

Binding peptide | BP | Haptoglobin alpha chain | Haptoglobin alpha(1S) beta | Haptoglobin alpha(2FS) beta | Haptoglobin beta chain | Haptoglobin, alpha polypeptide | Haptoglobin, beta polypeptide | HP | HP2 ALPHA2 | HP2ALPHA2 | HPA1S | HPT | HPT_HUMAN | M

rp214491-10μg

10μg

无动物源

≥95%(SDS-PAGE)

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Immobilized Recombinant Human Haptoglobin Protein (rp214491) at 1.0 μg/mL can bind Recombinant Haptoglobin Antibody (Ab008379) with the EC50 of 7.2 ng/mL.

重组表达

44.2 kDa

C-His

18.0 & 42.5 & 58.1 kDa, under reducing conditions; 250.0 kDa, under non-reducing conditions.

HEK293 Accession #: P00738 | HEK293

<1.0 EU/μg

人(Human)

1-406 aa

MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAENHHHHHH

Yes

Yes