Recombinant Human NF-L Protein

重组人 NF-L 蛋白 | 重组人神经丝轻链蛋白

68 kDa neurofilament protein | CMT2E | NEFL | neurofilament protein, light chain | neurofilament subunit NF-L | Neurofilament triplet L protein | neurofilament, light polypeptide | neurofilament-light | NF68 | NF68FLJ53642 | NFL | NF-L | NFLlight polypept

rp214494-10μg

10μg

无载体

≥90%(SDS-PAGE)

Neurofilament light polypeptide (NF-L), also known as 68 kDa neurofilament protein, and neurofilament triplet L protein, is an approximately 68 kDa member of the neuronal intermediate filament family that plays a role in the maintenance of neuronal caliber and possibly the pathogenesis of motor neuron diseases. Out of the three intermediate filament proteins (NF-L, NF-M, NF-H), NF-L is the most abundant. NF-L is a 542 amino acid (aa) cytoskeletal protein which consists of a 91 aa N-terminal head, a 304 aa alpha -helical rod, and a 147 aa C-terminal tail. Within the extracellular domains, human NF-L shares 95% and 96% sequence identity with mouse and rat NF-L, respectively. Post-translational: O-glycosylated. Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. Ubiquitinated in the presence of TRIM2 and UBE2D1.

重组表达

39.4 kDa

C-His

38.3 kDa, under reducing conditions

E. coli Accession #: P07196 | E. coli

<1.0 EU/μg

人(Human)

1-338 aa

MSSFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDHHHHHH

No

Yes