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Product details

名称

Recombinant Human SOX2 Protein

别名

重组人SOX2蛋白 | 重组人转录因子 SOX-2蛋白

英文别名

ANOP3 | cb236 | Delta EF2a | lcc | MCOPS3 | MGC148683 | MGC2413 | RGD1565646 | Sex determining region Y box 2 | SOX 2 | Sox2 | SOX2_HUMAN | SRY (sex determining region Y) box 2 | SRY box containing gene 2 | SRY related HMG box 2 | SRY related HMG box gene

货号

rp216657-10μg

包装规格

10μg

级别

无载体

浓度

≥90%(SDS-PAGE)

生化机理

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). Post-translational: Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. Methylation at Lys-42 and Lys-117 is necessary for the regulation of SOX2 proteasomal degradation. Ubiquitinated by WWP2, leading to proteasomal degradation.

来源

重组表达

预测分子量

20.0 kDa

蛋白标签

N-His

SDS-PAGE

22.7 kDa, under reducing conditions; 23.2 & 45.0 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P48431 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

135-317 aa

序列

MHHHHHHGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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