Recombinant Human JAK1 Protein

重组人JAK1蛋白 | 重组人非受体酪氨酸激酶蛋白

JAK 1 | JAK 1A | JAK 1B | JAK-1 | JAK1 | JAK1_HUMAN | JAK1A | JAK1B | Janus kinase 1 | Janus kinase 1 (a protein tyrosine kinase) | JTK3 | Tyrosine protein kinase JAK 1 | Tyrosine protein kinase JAK1 | Tyrosine-protein kinase JAK1

rp217131-10μg

10μg

无载体

≥80%(SDS-PAGE)

Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway(PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952). Kinase partner for the type I interferon receptor IFNAR2 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). Post-translational: Autophosphorylated (PubMed:7615558). Phosphorylated by TYK2 on tyrosine residues in response to type-I interferon signaling, leading to its activation (PubMed:8232552). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529). Ubiquitinated by RNF125; leading to its degradation by the proteasome.

重组表达

30.7 kDa

N-His

28.2 kDa, under reducing conditions

E. coli Accession #: P23458 | E. coli

<1.0 EU/μg

人(Human)

32-286 aa

MHHHHHHPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIF

No

Yes