Recombinant Human MSH2 Protein

重组人MSH2蛋白 | 重组人DNA错配修复酶蛋白

BAT26 | COCA 1 | COCA1 | DNA mismatch repair protein Msh2 | FCC 1 | FCC1 | hMSH2 | HNPCC | HNPCC 1 | HNPCC1 | LCFS2 | MSH 2 | Msh2 | MSH2_HUMAN | MutS homolog 2 | MutS homolog 2 colon cancer nonpolyposis type 1 | MutS protein homolog 2

rp217163-10μg

10μg

无载体

≥95%(SDS-PAGE)

MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines the DNA damage response.MSH2 is a central component of the mismatch repair pathway that targets mismatches arising during DNA replication, homologous recombination (HR), and in response to genotoxic stresses.MSH2 rearrangements are involved in approximately 10% of hereditary non-polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon 1 is deleted. Loss of human MSH2 (hMSH2) protein might be involved in the multistep pathogenesis of hematological malignancies associated with genetic instability. Post-translational: Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway. Sequentially deacetylated and polyubiquitinated by HDAC6, leading to MSH2 degradation.

重组表达

16.6 kDa

N-His

15.2 kDa, under reducing conditions; 15.2 kDa, under non-reducing conditions.

E. coli Accession #: P43246 | E. coli

<1.0 EU/μg

人(Human)

2-140 aa

MHHHHHHAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNND​

No

Yes