Recombinant Human STAT5A Protein

重组人STAT5A蛋白 | 重组人信号转导和转录激活因子5A蛋白

Mammary gland factor | MGF | Signal transducer and activator of transcription 5A | STA5A_HUMAN | STAT 5 | STAT 5A | STAT5 | STAT5A

rp217608-10μg

10μg

无载体

≥90%(SDS-PAGE)

Signal transducers and activators of transcription 5 (STAT5) has been shown to be involved in a variety of cellular processes, including survival, proliferation, invasion, angiogenesis and immune evasion and is frequently overexpressed in human solid tumors and blood malignancies. STAT5a/b species are well known as transcription factors that regulate nuclear gene expression. Using enucleated cytoplasts for a nongenomic mechanism(s) underlying the cystic change in ER structure elicited by STAT5a/b knockdown. Post-translational: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:14504097). Alternatively, can be phosphorylated by JAK2 at Tyr-694 (PubMed:12529425). ISGylated.

重组表达

24.7 kDa

N-His

29.1 kDa, under reducing conditions; 29.1 & 30.5 & 58.4 kDa, under non-reducing conditions.

E. coli Accession #: P42229 | E. coli

<1.0 EU/μg

人(Human)

583-794 aa

MHHHHHHKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS

No

Yes