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Product details

名称

重组人胎球蛋白B

别名

重组人Fetuin B蛋白 | 胎球蛋白B

英文别名

货号

rp218665-10μg

包装规格

10μg

级别

无动物源

浓度

≥90%(SDS-PAGE&SEC-HPLC)

产品介绍

胎球蛋白-B (FETUB) 属于胎球蛋白家族，是胱抑素超家族蛋白的一部分，由 2 个胱抑素结构域组成。胎球蛋白-B 在血清中以分泌形式存在，在肝脏、舌头和胎盘中表达。 FETUB 通过抑制矿化作用来调节成骨。胎球蛋白涉及许多不同的功能，包括成骨和骨吸收、肝细胞生长因子受体的调节以及对全身炎症的反应。 FETUB 在卵母细胞成熟中也发挥作用。胎球蛋白-B 对于预防受精前透明带过早硬化至关重要，可能是通过抑制 ASTL 的蛋白酶活性来实现的，ASTL 是一种介导 ZP2 裂解并引发透明带硬化的蛋白酶。本产品用重组HEK293，表达生产人Fetuin B，高纯度，高活性，无动物源性污染。

生化机理

Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity).

生物活性

Measured by its ability to inhibit active Cathepsin V cleavage of a fluorogenic peptide substrate Z-LR-AMC (RLU). The IC50 value is ≤100nM.

来源

重组表达

预测分子量

41 kDa

蛋白标签

No tag

SDS-PAGE

55-58 kDa, under reducing conditions.

表达系统

HEK293 Accession #: Q9UGM5 | HEK293

内毒素水平

<0.01 EU/μg

种属

人(Human)

氨基酸

19-382 aa

序列

MSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPTNLPKVEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPKEKARTAECPGPAQNASPLVLPP

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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