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Product details

名称

Recombinant Canine CD8 Protein

别名

重组狗CD8蛋白 | 重组狗T淋巴细胞表面糖蛋白蛋白

英文别名

CD8 | CD8A

货号

rp223889-10μg

包装规格

10μg

级别

无动物源

浓度

≥90%(SDS-PAGE)

生化机理

CD8, also known as Ly2 or Leu2, is a heterodimeric glycoprotein (alpha and beta subunits) that functions in conjunction with the T cell receptor in the recognition of MHC class I/peptide complexes. CD8 alpha is expressed on double positive (CD4+ CD8+) thymocytes and mature CD8+ cytolytic T cells (CTL), intraepithelial lymphocytes (IEL), some gamma delta T cells, subsets of thymic and splenic dendritic cells (DC), and peritoneal mast cells. It can form disulfide linked homodimers or heterodimers with CD8 beta. Thymic CD8+ DC express primarily alpha beta heterodimers, while splenic CD8+ DC primarily express alpha alpha homodimers. CD8a+ DC can present viral antigenic peptides in complex with MHC I and prime CTL responses. The approximately 35 kDa mature mouse CD8 alpha consists of a 169 amino acid (aa) extracellular domain (ECD) with one Iglike domain, a 21 aa transmembrane segment, and a 30 aa cytoplasmic domain. Within the ECD, mouse CD8 alpha shares 49% and 64% aa sequence identity with human and rat CD8 alpha, respectively. Post-translational: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts. O-glycosylated. Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.

来源

重组表达

预测分子量

18.8 kDa

蛋白标签

No tag

SDS-PAGE

26.0-31.3 kDa, under reducing conditions; 25.3-31.6 kDa, under non-reducing conditions.

表达系统

CHO Accession #: P33706 | CHO

内毒素水平

<1.0 EU/μg

种属

狗(Canine)

氨基酸

1-186 aa

序列

MASRVTALLLPLALLLRAAAASGPSRFRMTPPKVVGQLHAQVELQCQVLLSTAAPGCSWLYQRNEPAARPVFLMYISQSRAKPAEGLDTKHISGQKKTDSTYSLTLSRFRKEDEGYYFCSVLSNSILYFSPFVPVFLPVKPPTTPAPRPPTRAPTNASKPVSPRGETCRPAAGSAVKTSGLDFACEENLYFQ

无动物源

Yes

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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