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名称

Recombinant Human IGF-I/IGF-1 Protein

别名

重组人IGF-I/IGF-1蛋白 | 重组人胰岛素样生长因子1蛋白

英文别名

货号

rp223891-10μg

包装规格

10μg

级别

无载体

浓度

≥90%(SDS-PAGE)

生化机理

Insulin-like growth factor 1 (IGF-1 or IGF-I), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-1 is synthesized as two precursor isoforms with N- and alternate C‑terminal propeptides. These isoforms are differentially expressed by various tissues. The 7.6 kDa mature IGF‑1 is identical between isoforms and is generated by proteolytic removal of the N- and C‑terminal regions. Mature human IGF-1 shares 94% and 96% aa sequence identity with mouse and rat IGF-1, respectively, and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF2. Circulating IGF-1 is produced by hepatocytes, while local IGF-1 is produced by many other tissues in which it has paracrine effects. IGF-1 induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. IGF-1 regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism. It plays an important role in muscle regeneration and tumor progression. IGF-1 binds IGF1R, IGF2R, and the insulin receptor, although its effects are mediated primarily by IGF1R. IGF-1 association with IGF binding proteins increases its plasma half‑life and modulates its interactions with receptors.

生物活性

Measured in a cell proliferation assay using MCF-7 human breast cancer cell line. The ED50 for this effect is typically 7.9 ng/mL.

来源

重组表达

预测分子量

7.7 kDa

蛋白标签

No tag

SDS-PAGE

7.6 kDa, under reducing conditions; 7.6 & 15.1 & 19.8 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P05019 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

49-118 aa

序列

GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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