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Product details

名称

Recombinant Human IL-6 Protein

别名

重组人IL-6蛋白 | 重组人白细胞介素6蛋白

英文别名

货号

rp228960-10μg

包装规格

10μg

级别

无载体

浓度

≥95%(SDS-PAGE)

生化机理

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity. Post-translational: N- and O-glycosylated.

生物活性

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.16 ng/mL.

来源

重组表达

预测分子量

21.0 kDa

蛋白标签

No tag

SDS-PAGE

19.6 kDa, under reducing conditions; 18.9 & 41.8 kDa, under non-reducing conditions.

表达系统

E. coli Accession #: P05231 | E. coli

内毒素水平

<1.0 EU/μg

种属

人(Human)

氨基酸

29-212 aa

序列

SPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM

无动物源

无载体

Yes

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

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