甲氧沙林,英文名:Methoxsalen,CAS:298-81-7,化学式:C12H8O4,分子量:216.19,密度:1.1344 (rough estimate),熔点:148-150°C(lit
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298-81-7
甲氧沙林(Methoxsalen)
CAS: 298-81-7
化学式: C12H8O4
| 中文名 | 甲氧沙林 |
| 英文名 | Methoxsalen |
| 别名 | 黄原毒 甲氧沙林 花椒毒素 甲氧扫若仑 甲氧补骨脂素 氧化补骨脂素 8-甲氧补骨脂 甲氧基补骨脂素 甲氧沙林-D3 8-甲氧补骨脂素 8-甲氧基补骨酯 8-甲氧基补骨脂素 |
| 英文别名 | MOP 8-MP 8-MOP Uvadex Meloxine Ammoidin xanthoxin 8-Methoxy Oxsoralen meladinin methoxalen zanthotoxin Methoxsalen Xanthotoxin oxypsoralen Psoralon-MOP psoralen-mop Methoxa-Dome proralone-mop 7-furocoumarin Oxsoralen Ultra Oxsoralen Lotion 9-Methoxypsoralen 8-Methoxypsoralen 8-Methoxyfuranocoumarin 8-methoxy-4',5',6,7-furocoumarin 8-methoxy-2',3',6,7-furocoumarin 8-Methoxy-2',3',6,7-furocoumarin 8-methoxy-2',3',6,7-furocoumarin 8-Methoxy-4',5',6,7-furocoumarin 9-methoxyfuro[3,2-g]chromen-7-one 9-methoxy-7H-furo[3,2-g]chromen-7-one 9-methoxy-7H-furo(3,2-g)benzopyran-7-one 2-g][1]benzopyran-7-one,9-methoxy-7h-furo[ 2-g)(1)benzopyran-7-one,9-methoxy-7h-furo( 6-hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone |
| CAS | 298-81-7 |
| EINECS | 206-066-9 |
| 化学式 | C12H8O4 |
| 分子量 | 216.19 |
| InChI | InChI=1/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3 |
| 密度 | 1.1344 (rough estimate) |
| 熔点 | 148-150°C(lit.) |
| 沸点 | 276.6°C (rough estimate) |
| 闪点 | 204.7°C |
| 水溶性 | PRACTICALLY INSOLUBLE |
| 蒸汽压 | 4.33E-07mmHg at 25°C |
| 溶解度 | H2O: 微溶 |
| 折射率 | 1.4270 (estimate) |
| 存储条件 | Sealed in dry,Room Temperature |
| 敏感性 | Sensitive to light |
| 外观 | 针状晶体或粉末 |
| 颜色 | white to yellow |
| Merck | 14,5988 |
| BRN | 196453 |
| 物化性质 | 可溶于沸乙醇、乙酸、丙二醇、氯仿和苯，微溶于沸水、液体石蜡和乙醚，不溶于冷水。 来源于芸香科植物崖椒(Fagava zanthoxyloides Lam.)的果实 |
| MDL号 | MFCD00005009 |
| 危险品标志 | Xn - 有害物品 T - 有毒物品 |
| 风险术语 | R22 - 吞食有害。 R43 - 与皮肤接触可能致敏。 R46 - 可能引起遗传性基因损害。 R45 - 可能致癌。 R34 - 引起灼伤。 |
| 安全术语 | S36/37 - 穿戴适当的防护服和手套。 S53 - 避免接触，使用前须获得特别指示说明。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 |
| 危险品运输编号 | 3216 |
| WGK Germany | 3 |
| RTECS | LV1400000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| 海关编号 | 29322090 |
| 上游原料 | 重氮甲烷 |
| 下游产品 | 5-羟基-8-甲氧基补骨脂素 |
| 参考资料 展开查看 | 1. 董玉鹏 孙萍 李永才 毕阳 张苗 黄怡 张婷婷.反式-2-己烯醛对梨果黑斑病菌Alternaria alternata的抑菌作用及其机理[J].食品科学 2020 41(07):191-197. 2. 王雪莲, 李敏敏, 胡军华,等. 18种香豆素类化合物对柑桔炭疽菌的抑制作用[J]. 中国南方果树, 2013, 42(004):73-74. 3. 吴雯 吴锐枫 康江丽. 参苓健体粉指纹图谱和含量测定方法的研究[J]. 中国药师 2019 22(05):852-856. 4. 张平, 马潇, 李冬华,等. 白芷饮片全国评价性抽验结果分析与多指标成分一测多评法研究[J]. 中草药, 2019(14). 5. 于兰,唐辉,陈韩英,王晓琴,张波.甲氧基黄酮促斑马鱼黑色素生成的药效学评价及机制研究[J].中草药,2020,51(23):6023-6034. 6. Yang, Yan-Fang, Lei Zhang, and Xiu-Wei Yang. "Distribution assessments of coumarins from Angelicae Pubescentis Radix in rat cerebrospinal fluid and brain by Liquid Chromatography Tandem Mass Spectrometry analysis." Molecules 23.1 (2018): 225.https://doi.or 7. [IF=7.514] Si-Duo Zhou et al."On-line screening and identification of free radical scavenging compounds in Angelica dahurica fermented with Eurotium cristatum using an HPLC-PDA-Triple-TOF-MS/MS-ABTS system."Food Chem. 2019 Jan;272:670 8. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 9. [IF=4.411] Liang Yang et al."New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum."Molecules. 2016 Apr;21(4):468 10. [IF=3.963] Zhongxiang Sun et al."Identification of a cytochrome P450 CYP6AB60 gene associated with tolerance to multi-plant allelochemicals from a polyphagous caterpillar tobacco cutworm (Spodoptera litura)."Pestic Biochem Phys. 2019 Feb;154:60 11. [IF=3.943] Liwei He et al."4(3H)-Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG-1 pathway in RAW264.7 cell."Int Immunopharmacol. 2017 Nov;52:245 12. [IF=5.81] Jiye Wang et al."Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods."Front Pharmacol. 2021; 12: 754175 13. [IF=5.753] Liu Man et al."Constructing a Core Collection of the Medicinal Plant Angelica biserrata Using Genetic and Metabolic Data."Front Plant Sci. 2020 Dec;0:2099 14. [IF=4.36] Yang Zhao et al."Shashen-Maidong Decoction improved chronic intermittent hypoxia-induced cognitive impairment through regulating glutamatergic signaling pathway."J Ethnopharmacol. 2021 Jun;274:114040 |
