The Ministry of Public Security and other six departments jointly issued an announcement to list 7 substances including 4- (N-phenylamino) piperidine in the management of precursor chemicals

2026-03-27 10:24:45

                                                                   The Ministry of Public Security and other six departments jointly issued an announcement to list 7 substances including 4- (N-phenylamino) piperidine in the management of precursor chemicals
                                                                                                                          National Narcotics Control Office 
In order to strengthen the management of precursor chemicals, the Ministry of Public Security, the Ministry of Commerce, the National Health Commission, the Ministry of Emergency Management, the General Administration of Customs, and the State Drug Administration jointly issued an announcement on August 2, 2024,

Decided to list seven substances including 4- (N-phenylamino) piperidine in the management of precursor chemicals. The announcement will take effect on September 1, 2024.

Annex: "On the use of 4- (N-phenylamino) piperidine, 1-tert-butoxycarbonyl-4- (N-phenylamino) piperidine, N-phenyl-N- (4-piperidinyl) propionamide, cannabidiol, 2-methyl-3-phenylglycidyl and

Its esters, 3-oxo-2-phenylbutyric acid and its esters, 2-methyl-3- [3,4- (methylenedioxy) phenyl] glycidyl esters are listed in the announcement on the management of precursor chemicals

Regarding the use of 4- (N-phenylamino) piperidine, 1-tert-butoxycarbonyl-4- (N-phenylamino) piperidine, N-phenyl-N- (4-piperidinyl) propionamide, cannabidiol, 2-methyl-3-phenylglycidyl acid and its esters,

Announcement on the listing of 3-oxo-2-phenylbutyric acid and its esters, 2-methyl-3- [3,4- (methylenedioxy) phenyl] glycidyl esters in the management of precursor chemicals


Approved by the State Council, 4- (N-phenylamino) piperidine, 1-tert-butoxycarbonyl-4- (N-phenylamino) piperidine, N-phenyl-N- (4-piperidinyl) propionamide, cannabidiol, 2-methyl-3-phenylglycidyl acid

And its esters, 3-oxo-2-phenylbutyric acid and its esters, 2-methyl-3- [3,4- (methylenedioxy) phenyl] glycidyl esters 7 substances are listed in the "Regulations on the Administration of Precursor Chemicals"

(Hereinafter referred to as the "Regulations") Schedule "Catalogue of Classifications and Varieties of Precursor Chemicals", the relevant management matters are hereby announced as follows:


Management of 1, 4- (N-phenylamino) piperidine, 1-tert-butoxycarbonyl-4- (N-phenylamino) piperidine, and N-phenyl-N- (4-piperidinyl) propionamide


4- (N-phenylamino) piperidine, referred to as 4-AP, CAS No. 23056-29-3, customs code 2933399099; 1-tert-butoxycarbonyl-4- (N-phenylamino) piperidine,

Abbreviation 1-boc-4-AP, CAS number 125541-22-2, customs code 2933399099; N-phenyl-N- (4-piperidinyl) propionamide, English name Norfentanyl, commonly known as dephenethylfentanyl,

The CAS number is 1609-66-1 and the customs code is 2933399099. The above three substances are managed in accordance with the second category of precursor chemicals in the Schedule to the Regulations. Their production, operation, purchase, transportation, import and export

Activities to implement the relevant provisions of non-pharmaceutical precursor chemicals.


II. Management of cannabidiol

Cannabidiol, English name Cannabidiol, referred to as CBD, CAS number 13956-29-1, customs code 2907299090. This substance is managed in accordance with the second category of precursor chemicals in the Schedule to the Regulations

, its production, operation, purchase, transportation and import and export activities comply with the relevant provisions of non-pharmaceutical precursor chemicals. Preclinical studies of cannabidiol for medical purposes should also comply with the "Narcotic Drugs and

Article 10 of the Regulations on the Administration of Psychotropic Drugs.


Management of tris, 2-methyl-3-phenylglycidyl acid and its esters, 3-oxo-2-phenylbutyric acid and its esters, and 2-methyl-3- [3,4- (methylenedioxy) phenyl] glycidyl esters


2-Methyl-3-phenylglycidyl acid, English name BMK glycidic acid, CAS number 25547-51-7, customs code 2918990090; 2-methyl-3-phenylglycidyl esters, yes

Refers to esters formed by the reaction of 2-methyl-3-phenyl glycidyl acid with various alcohols, the English name is BMK glycidic acid esters, customs code 2918990090.


3-Oxo-2-phenylbutyric acid, English name 3-oxo-2-phenylbutanoic acid, CAS number 4433-88-9, customs code 2918300090; 3-oxo-2-phenylbutyric acid esters, refers to

Esters formed by the reaction of 3-oxo-2-phenylbutyric acid with various alcohols, English name is 3-oxo-2-phenylbutanoic acid esters, customs code 2918300090. Listed

Methyl 3-oxo-2-phenylbutyrate (CAS No. 16648-44-5) in the Catalogue of Classification and Varieties of Precursor Chemicals is controlled according to the original catalogue.


2-Methyl-3- [3,4- (methylenedioxy) phenyl] glycidyl esters, refers to the reaction of 2-methyl-3- [3,4- (methylenedioxy) phenyl] glycidyl acid (second class precursor chemicals) with various alcohols

Synthetic esters, English name PMK glycidic acid esters, customs code 2932999099. 2-methyl-3- [3,4- (methylene dioxy) listed in the "Catalogue of Classification and Varieties of Precursor Chemicals"

Phenyl] methyl glycidylate (CAS No. 13605-48-6) is controlled according to the original catalogue.

The above three substances are managed in accordance with the second category of precursor chemicals in the Schedule to the Regulations, and their production, operation, purchase, transportation, and import and export activities are subject to the relevant provisions of non-pharmaceutical precursor chemicals.This announcement shall come into force on September 1, 2024.


Ministry of Public Security, Ministry of Commerce, National Health Commission

Ministry of Emergency Management, General Administration of Customs, State Drug Administration

August 2, 2024


The content is sourced from the National Narcotics Control Office  

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