- exposure pathway： 口服。胃肠道吸收均匀、迅速且基本完全。
- Harmful effect： 总的来说，格列吡嗪是一种相对安全的口服降糖药，不良反应的风险非常低。
- Toxicity summary： 磺脲类药物可能结合到胰腺细胞表面的ATP敏感性钾通道受体上，减少钾电导并导致膜去极化。去极化通过电压敏感性钙通道刺激钙离子内流，提高细胞内钙离子浓度，从而诱导胰岛素的分泌或胞吐作用。
- Toxicity Data： 在所有测试物种中，急性口服毒性极低(LD50大于4 g/kg)。
- Primary Hazards： 未分类
- Symptoms and Signs： 所有测试物种的急性口服毒性极低（LD50 大于 4 g/kg）。包括格列吡嗪在内的磺酰脲类药物过量可导致低血糖。
- Hazard categories and classifications： 未分类
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： 截至修订日期，未找到相关已发表信息。
- USGS Health-Based Screening Levels for Evaluating Water-Quality： 参考文献: Smith, C.D. and Nowell, L.H., 2024. 用于评估水质数据的基于健康的标准水平 (第 3 版)。DOI:10.5066/F71C1TWP
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Research chemical 50mg
Research chemical 50mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 50mg.
