- exposure pathway： 在正常受试者皮肤外用后，硝酸益康唑的全身吸收极低。尽管大部分药物仍留在皮肤表面，但在角质层中发现的药物浓度远超过对皮肤癣菌的最低抑菌浓度。
- Toxicity summary： 益康唑与14-α脱甲基酶相互作用，这是一种将羊毛甾醇转化为麦角甾醇所需的细胞色素P-450酶。由于麦角甾醇是真菌细胞膜的必需成分，抑制其合成会导致细胞通透性增加，引起细胞内容物泄漏。益康唑还可抑制内源性呼吸，与膜磷脂相互作用，抑制酵母菌向菌丝形态的转化，抑制嘌呤摄取，并损害甘油三酯和/或磷脂的生物合成。
- Toxicity Data： LD50: 462 mg/kg (口服，小鼠) (A308) LD50: 462 mg/kg (口服，大鼠) (A308) LD50: 668 mg/kg (口服，豚鼠) (A308) LD50: >160 mg/kg (口服，狗) (A308)
- Hazard categories and classifications： 急性毒性4级 (97.4%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响
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Research chemical ≥98. 0%; 100mg
Research chemical ≥98. 0%; 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥98. 0%; 100mg.
