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Product introduction
去氧肾上腺素是苯乙醇胺类化合物,是(1R)-2-(甲基氨基)-1-苯基乙醇-1-醇,在苯环的3位具有额外的羟基取代基。它具有拟交感神经药、α-肾上腺素能激动剂、强心药、保护剂、散瞳剂、血管收缩剂和鼻减充血剂的作用。它是苯乙醇胺、酚类和仲胺化合物的成员。它是去氧肾上腺素(1+)的共轭碱。
Chinese name
去氧肾上腺素碱
English name
3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
Chinese alias
-
English alias
3-Hydroxy-alpha-((methylamino)methyl)-benzyl alcohol
CAS number
59-42-7
molecular formula
C9H13NO2
molecular weight
167.20
Exact mass
-
PSA
52.5
Logp
-0.3
Safety
  • Storage conditions: 在40°C (104°F)以下储存,最好在15至30°C (59和86°F)之间,除非制造商另有说明。如果不超过15毫升,应存放在密封、避光的容器中。防止冻结。
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • Harmful effect: α1肾上腺素能拮抗剂:这些拮抗剂直接抑制平滑肌上的α1受体,对抗去氧肾上腺素的血管收缩作用。
  • Toxicity summary: 目前,尚无已知的静脉注射去氧肾上腺素解毒剂。因过量给药或过度反应导致的高血压通常是短暂的,主要由于其作用时间短。高血压或症状性反射性心动过缓的治疗包括停止给予去氧肾上腺素,并根据需要给予正性频率药物或血管扩张剂。外周给予的去氧肾上腺素引起的组织外渗治疗主要包括支持性护理,包括液体抽吸、保暖和抬高。在某些情况下,也可考虑皮下给予酚妥拉明。
  • Regulatory information: REACH注册物质:状态:停止制造更新:2012-12-19 https://echa.europa.eu/registration-dossier/-/registered-dossier/7827
  • Special Reports: DHHS/NTP;苯肾上腺素盐酸盐的毒理学与致癌性研究(F344/N大鼠和B6C3F1小鼠)(饲料研究)技术报告系列第322号(1987) NIH出版物第87-2578号
  • FDA Requirements: 眼科血管收缩剂。产品的活性成分由以下一种或多种组成,每种成分在规定浓度范围内。盐酸去氧肾上腺素,0.08%至0.2%。
  • Other safety information: 化学品评估:IMAP评估 - 苯甲醇, 3-羟基-.α.-[(甲基氨基)甲基]-, (R)-: 人类健康I级评估
  • Hazard categories and classifications: 急性毒性 4 (100%)
  • Antidote and first aid: 增强消除。透析和血液灌注无效。尿液酸化可能增强去氧麻黄碱、麻黄碱和伪麻黄碱的消除,但如果患者横纹肌溶解,也可能加重肾脏中的肌红蛋白沉积。/伪麻黄碱、苯肾上腺素和其他减充血剂/
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Populations at Special Risk: 应极其谨慎地给予老年患者、甲状腺功能亢进患者或患有心动过缓、部分性心脏传导阻滞、心肌疾病或严重动脉硬化的患者。然而,一些临床医生认为严重的冠心病或心血管疾病(包括心肌梗死)是使用去氧肾上腺素的禁忌症。对于高血压患者,如需静脉给予去氧肾上腺素,应极其谨慎。去氧肾上腺素禁用于严重高血压或室性心动过速患者以及对药物过敏的患者。如果给予急性胰腺炎或肝炎患者,该药物可能增加肝脏或胰腺的缺血。去氧肾上腺素不应用于外周...
  • Effects During Pregnancy and Lactation: 尚未进行研究以确定去氧肾上腺素是否会影响生育能力或增加出生缺陷的风险。通常,父亲或精子捐献者的暴露不太可能增加妊娠风险。有关更多信息,请参阅MotherToBaby事实表父系暴露,网址为https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/。
Related
upstream information
Manufacturing method:
甲胺(CID:6329);盐酸(CID:313);甲醇(CID:887);去氧肾上腺素(CID:6041);去氧肾上腺素盐酸盐(CID:6102)
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Research chemical ≥98. 0%; 10mg

Research chemical ≥98. 0%; 10mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥98. 0%; 10mg.

item number:717346-10mg
Product model:10mg
level: ≥98. 0%; 10mg
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