截短侧耳素是有效的二萜类抗生素，对革兰氏阳性细菌具有活性。该抗生素于1951年从白灵菇属中分离出来。|通过结晶和生化研究证明，截短侧耳素通过阻断底物与核糖体肽基转移酶中心的供体位点和受体位点的结合而起作用，从而抑制了该菌的生长。肽键形成。该化合物与其他化合物的交叉电阻最小，这归因于其作用方式。截短侧耳素靶向广泛的病原体，已用于皮肤和呼吸道感染研究。 Pleuromutilin is a potent diterpene antibiotic with activity against gram-positive bacteria. The antibiotic was isolated in 1951 from the genus|Pleurotus.|It has been demonstrated through crystallization and biochemical research that Pleuromutilins acts by blocking substrate binding to the donor site and acceptor site of the ribosome's peptidyl-transferase center, which results in inhibition of the peptide bond formation. The compound encounters minimum cross-resistance with other compounds, which is attributed to its mode of action. Pleuromutilins targets a wide spectrum of pathogens and has been used in skin and respiratory tract infection studies.