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Product introduction
氯噻酮是异吲哚类、磺酰胺类和单氯苯类的成员。
Chinese name
氯塞酮
English name
2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
Chinese alias
-
English alias
2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide; Chlorthalidone; Hygroton; Thalitone
CAS number
77-36-1
molecular formula
C14H11ClN2O4S
molecular weight
338.8
Exact mass
-
PSA
118
Logp
0.9
Safety
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • Harmful effect: * 锂:接受锂治疗的个体需密切监测锂水平,因为利尿剂如氯噻酮可能减少锂的排泄,从而引发锂中毒。
  • Toxicity summary: * 支持性管理包括静脉输注葡萄糖或生理盐水治疗低血压,以及静脉输注氯化钾治疗严重低钾血症。
  • Regulatory information: 新西兰化学品清单状态:氯噻酮:没有单独批准,但可在适当的团体标准下使用
  • Special Reports: 氯噻酮胎盘转移及其在母乳中消除的研究。[MULLEY BA 等;氯噻酮的胎盘转移及其在母乳中的消除;EUR J CLIN PHARMACOL 13(2) 129-131 (1978)]
  • Human toxicity extract: 一名60岁女性因轻度高血压接受氯噻酮治疗后,出现了抗利尿激素分泌不当综合征。血清渗透压为235 MOSM/KG,同时尿液渗透压为490 MOSM/KG。
  • Other safety information: 化学品评估:IMAP评估 - 苯磺酰胺,2-氯-5-(2,3-二氢-1-羟基-3-氧代-1H-异吲哚-1-基)-:人类健康I级评估
  • Hazard categories and classifications: 特定靶器官毒性-单次接触 3级 (57.5%)
  • Antidote and first aid: 噻嗪类利尿剂过量应通过...支持性对症治疗和监测血清电解质浓度及肾功能来治疗。/噻嗪类利尿剂/
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 氯噻酮已成功用于抑制泌乳,在分娩后立即口服200 mg,随后连续3天每天100 mg,同时限制液体摄入和乳房包扎。然而,一项比较研究发现,氯噻酮200 mg每天服用7.6天与安慰剂在乳汁泄漏和乳房胀痛方面没有差异。利尿剂对限制液体摄入和乳房包扎(这些方法可有效抑制泌乳)的附加作用尚未研究。尚无关于利尿剂对已建立的持续泌乳影响的数据。
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upstream information
Manufacturing method:
3-氨基-4-氯二苯甲酮 (CID:10799548); 二氧化硫 (CID:1119); 亚硫酰氯 (CID:24386); 氨 (CID:222); 氯仿 (CID:6212); 乙醇 (CID:702); 氯噻酮 (CID:2732)
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Research chemical 97. 9%; 50mg

Research chemical 97. 9%; 50mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 97. 9%; 50mg.

item number:76840
Product model:50mg
level: 97. 9%; 50mg
Lead Time:-
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