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Product introduction
根据州或联邦政府标签要求,氟比洛芬可导致发育毒性和女性生殖毒性。
Chinese name
氟比洛芬, ASIC1 通道阻断剂
English name
2-(3-fluoro-4-phenylphenyl)propanoic acid
Chinese alias
-
English alias
2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid | FLURBIPROFEN [MART.] | Flurofen | Prestwick1_000917 | U 27,182 | U-27,182 | Zepolas | Adfeed | Flurbiprofen (Ansaid) | 2-Fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic acid | (.+/-.)-Flurbiprofen | Spectrum5
CAS number
5104-49-4
molecular formula
C15H13FO2
molecular weight
244.26
Exact mass
-
PSA
37.3
Logp
4.2
Safety
  • Treatment: 患者应在非甾体抗炎药过量后通过症状和支持性护理进行管理。没有特定的解毒剂。对于在摄入后4小时内出现症状的患者,或大量过量(通常剂量的5-10倍)后,可能需要催吐和/或活性炭(成人60-100克,儿童1-2克/千克)和/或渗透性泻药。由于高蛋白结合,强制利尿、尿液碱化、血液透析或血液灌注可能没有用。(L1712)
  • exposure pathway: 口服给药后,氟比洛芬迅速且几乎完全吸收。口服给药后0.5-4小时达到血浆峰浓度。
  • Toxicity summary: 与其他非甾体抗炎药(NSAIA)类似,氟比洛芬的抗炎作用是通过可逆性抑制环氧化酶(COX)实现的,该酶负责前列腺素合成途径中花生四烯酸转化为前列腺素G2 (PGG2)以及PGG2转化为前列腺素H2 (PGH2)。这有效降低了参与炎症、疼痛、肿胀和发热的前列腺素浓度。氟比洛芬是一种非选择性COX抑制剂,抑制COX-1和COX-2的活性。在前列腺素抑制活性方面,它也是最有效的NSAIA之一。
  • Regulatory information: 加州化妆品安全计划(CSCP)报告成分:报告 - 无论成分在产品中的预期功能如何
  • Toxicity Data: LD50:10毫克/千克(口服,狗)(A308)
  • Hepatotoxicity: 可能性评分:C(可能是引起明显肝损伤的罕见原因)。
  • Symptoms and Signs: 氟比洛芬过量的症状可能包括恶心、呕吐、胃痛、头晕、嗜睡、黑色或带血粪便、咳血、尿量减少或无尿、呼吸浅表、昏厥或昏迷。
  • Other safety information: 化学品评估:IMAP评估 - [1,1'-联苯]-4-乙酸,2-氟-.alpha.-甲基-:人类健康I级评估
  • Hazard categories and classifications: Repr. 2 (50%)
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
  • Drug Induced Liver Injury: 参考: DOI:10.1016/j.drudis.2011.05.007
  • Effects During Pregnancy and Lactation: 截至修订日期,未找到相关已发表信息。
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Research chemical ≥98. 0%; 100mg

Research chemical ≥98. 0%; 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥98. 0%; 100mg.

item number:76856
Product model:100mg
level: ≥98. 0%; 100mg
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