- Hazard summary： 在急性脑研究中导致大鼠脑部退行性变化；[RTECS] 除非纯净并储存在密封容器中，否则会聚合和分解；用作食品调味剂时安全；[JECFA] 导致烧伤；吸入可能导致上呼吸道和肺部腐蚀性损伤；[Sigma-Aldrich MSDS]
- exposure pathway： 丙酮酸从胃肠道吸收，然后通过门静脉循环运输到肝脏。
- Harmful effect： 毒性肺炎 - 因吸入金属烟雾或有毒气体和蒸汽引起的肺部炎症。
- Toxicity summary： 丙酮酸通过转化为乙酰辅酶A作为生物燃料，进入三羧酸循环或克雷布斯循环，在有氧条件下代谢产生ATP。能量也可以通过丙酮酸转化为乳酸的方式无氧获得。丙酮酸注射或灌注可增强心脏在代谢葡萄糖或脂肪酸时的收缩功能。这种正性肌力作用在缺血/再灌注性顿抑心脏中尤为显著。丙酮酸的正性肌力作用需要冠状动脉内输注。可能的机制包括ATP生成增加和ATP磷酸化电位提高。另一个机制是激活丙酮酸脱氢酶，通过抑制丙酮酸脱氢酶激酶促进其自身氧化。丙酮酸脱氢酶...
- Regulatory information： 新西兰 EPA 化学品状态清单: 丙酮酸: 没有单独批准，但可在适当的团体标准下使用
- Other safety information： 化学品评估：评估-不太可能需要进一步监管以管理环境风险的化学品
- Hazard categories and classifications： 眼睛损伤 1级 (83.2%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
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Research chemical 95. 0%; 100mg
Research chemical 95. 0%; 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 95. 0%; 100mg.
