- Toxicity summary： 氯甲噻嗪与中枢苯二氮卓受体结合，该受体与GABA受体变构相互作用。这增强了抑制性神经递质GABA的作用，增加了对上行网状激活系统的抑制，并阻断了网状通路刺激后发生的皮层和边缘系统的唤醒。
- interaction： 氯甲噻嗪可能会降低患者对酒精的耐受性...可能与氯甲噻嗪和中枢神经系统抑制剂(如酒精,吩噻嗪类,巴比妥类,麻醉药,其他精神治疗药物和单胺氧化酶抑制剂)产生协同作用.
- ecotoxicity value： USDA APHIS化学效应：collection=usda_chemeffect&query_type=synonym&query='^80-77-3$'
- Symptoms and Signs： 过量症状包括嗜睡、虚弱、恶心、头晕、腹痛、脑水肿和肾小管坏死、高血糖和低血糖、肝损伤、脑病、昏迷和死亡。
- Human toxicity extract： ...口服毒性小于甲丙氨酯,氯唑沙宗或美索巴莫...在临床试验中,4653名患者中只有2.3%出现副作用...服用高达10克的过量药物并未导致死亡.即使大量服用也只会产生轻微的副作用.
- Other safety information： 化学品评估：IMAP评估 - 4H-1,3-噻嗪-4-酮，2-(4-氯苯基)四氢-3-甲基-, 1,1-二氧化物：人类健康I级评估
- Hazard categories and classifications： 急性毒性 4 (100%)
- Non-human toxic extract： IN CHRONIC LAB STUDIES ONLY ADVERSE EFFECT NOTED WAS ATAXIA, @ HIGHEST DOSAGE LEVEL.
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
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Research chemical 1mL
Research chemical 1mL; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1mL.
