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Product introduction
甲喹酮是喹唑啉类化合物,是在喹唑啉-4-酮的2位和3位分别被甲基和邻甲苯基取代的化合物。它是一种能增强大脑和神经系统GABA受体活性的抑制剂,用作镇静催眠药物。它在1960年代末和1970年代作为娱乐性药物和俱乐部药物流行。它具有镇静剂和GABA激动剂的作用。
Chinese name
2-甲基-3-(2-甲基苯基)-4(3<i>H</i>)喹唑啉酮
English name
2-methyl-3-(2-methylphenyl)quinazolin-4-one
Chinese alias
安眠酮
English alias
4(3H)-Quinazolinone,2-methyl-3-o-tolyl- (6CI,8CI); (2-Methyl-3-(o-tolyl)-3,4-dihydro-4-(quinazolinone); (?à)-Methaqualone; 2-Methyl-3-(o-tolyl)quinazolone; 2-Methyl-3-o-tolyl-4(3H)-chinazolone; 2-Methyl-3-o-tolyl-4(3H)-quinazolinone; 2-Methyl-3-o-tolyl-4-
CAS number
72-44-6
molecular formula
C16H14N2O
molecular weight
250.29
Exact mass
-
PSA
32.7
Logp
2.5
Safety
  • Regulatory information: DEA管制物质:DEA I类管制物质
  • interaction: 在人体中,正常剂量使用3周后,安替比林或保泰松的半衰期没有显著变化,6β-羟基氢化可的松的排泄也没有变化,但在催眠药依赖的受试者中,安替比林半衰期中度缩短,效应小于巴比妥类药物依赖...
  • Special Reports: BROWN SS, GOENECHEA S; CLIN PHARMACOL THER 14(3): 314 (1973). 关于甲喹酮的化学、药代动力学和药理学综述。
  • FDA Requirements: 1984年,国会通过了立法(公共法98-329)...将甲喹酮从第二类转移到第一类...并撤销甲喹酮的市场批准。...甲喹酮已从美国市场撤出,并被列入《受控物质法》的第一类。
  • Other safety information: 化学品评估:IMAP评估 - 4(3H)-喹唑啉酮,2-甲基-3-(2-甲基苯基)-:人类健康一级评估
  • Hazard categories and classifications: 水生慢性4(100%)
  • Non-human toxic extract: 给怀孕大鼠服用甲喹酮增加了后代腭裂的发生率...
  • Antidote and first aid: 长期血液透析和腹膜透析可降低血浆水平(例如,在一例过量病例中,清除率分别为7.5和29 ml/min),但不会显著改变临床结果。血液灌流对甲喹酮的清除率优于血液透析(179 ml/min),但临床反应有限,可能是因为分布体积大和组织储存量大。血液甲喹酮水平超过40 ug/ml提示需要进行血液灌流。强制利尿是禁忌的,因为甲喹酮容易引起肺水肿。
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Research chemical 1mL

Research chemical 1mL; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1mL.

item number:91309GA
Product model:1mL
level: 1mL
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