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Product introduction

GW 501516 (GW 1516) 是 PPARδ 的激动剂，EC50 值为 1.1 nM。 GW501516 has been used to study its effect on mutation-driven colorectal tumorigenesis and tumor invasion using mouse model. GW501516 has been used as a peroxisome proliferator-activated receptor (PPAR) δ agonist: to treat the differentiated L6 myotubes to test its effect on free fatty acid (FFA) uptake under mild hypoxia conditions in organoid culture medium to test its effect on self-renewal of PR domain containing 16 (Prdm16)-depleted intestinal stem cells as a component in the defatting medium for primary human hepatocytes (PHH) culture

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Chinese name

GW501516,PPARδ激动剂, 过氧化物酶体增殖激活受体δ激动剂

English name

GW501516

Chinese alias

2-[2-甲基-4-[[[4-甲基-2-[4-(三氟甲基)苯基]-5-噻唑基]甲基]硫代]苯氧基]-乙酸

English alias

HMS3744O09 | HY-10838 | 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid | GW 501516 | SB19569 | AC-23001 | 2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy

CAS number

317318-70-0

molecular formula

C21H18F3NO3S2

molecular weight

453.5 g/mol

Exact mass

PSA

113.000 Å²

Logp

5.9

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