- exposure pathway： 口服后迅速吸收。在皮肤癣菌性甲癣患者中，对所有二十个指甲及相邻5毫米皮肤每日应用一次环吡酮，持续6个月，平均吸收量小于应用剂量的5%。环吡酮胺也能穿透毛发，并通过表皮和毛囊进入皮脂腺和真皮。
- Toxicity summary： 与影响固醇合成的抗真菌药物如伊曲康唑和特比萘芬不同，环吡酮被认为通过与多价金属阳离子（如Fe<sup>3+</sup>和Al<sup>3+</sup>）螯合作用发挥作用。这些阳离子抑制许多酶，包括细胞色素，从而破坏线粒体电子传递过程和能量产生等细胞活动。环吡酮似乎还能修饰真菌的质膜，导致内部结构紊乱。环吡酮的抗炎作用最可能是由于抑制了5-脂氧合酶和环氧化酶。环吡酮可能通过破坏DNA修复、细胞分裂信号和结构（有丝分裂纺锤体）以及细胞内运输的某些元素发挥作用。
- Toxicity Data： LD50：>10毫升/千克（口服，大鼠）（A308）
- Hazard categories and classifications： 眼睛刺激物 2 (96.6%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响
Warm reminder：
Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！
Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.
Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！
Research chemical 1mL
Research chemical 1mL; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1mL.
