Share to
Overview
Specs
Safety
Technical Documents
Related
Articles
reviews
Consult
returns
Product introduction
米安色林是二氮杂䓬(特别是1,2,3,4,10,14b-六氢二苯并[c,f]吡嗪并[1,2-a]氮杂䓬),在N-2位被甲基取代。与四环类抗抑郁药米氮平(现已大部分被取代)密切相关,它是一种非典型抗抑郁药,在欧洲及其他地区用于治疗抑郁症。它具有老年保护剂、抗抑郁药、肾上腺素摄取抑制剂、组胺激动剂、镇静剂、α-肾上腺素能拮抗剂、H1受体拮抗剂、血清素拮抗剂和EC 3.4.21.26(脯氨酸寡肽酶)抑制剂的作用。
Chinese name
米赛林
English name
5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene
Chinese alias
-
English alias
(?à)-Mianserin; Mianserin; Mianserine
CAS number
24219-97-4
molecular formula
C18H20N2
molecular weight
264.4
Exact mass
-
PSA
6.5
Logp
3.4
Safety
  • Body Burden: ...在一项前瞻性研究中,包括十名老年抑郁症患者(年龄60-77岁),在安慰剂治疗1周和米安色林60 mg/天治疗5周期间,观察到米安色林(13-57 ug/L)和主要代谢物去甲米安色林(7-27 ug/L)的血浆水平。
  • Regulatory information: 新西兰EPA化学品清单状态:米安色林:没有单独批准,但可在适当的团体标准下使用
  • interaction: 在正常志愿者和接受可乐定或甲基多巴的原发性高血压患者中评估了米安舍林与中枢性降压药的相互作用。给正常志愿者首次服用20毫克米安舍林时,出现了明显的镇静作用和体位性低血压。在正常志愿者中,单次口服300微克可乐定后的血压反应未因米安舍林预处理而改变。然而,单独使用可乐定引起的心动过缓显著减轻。在患者研究中,首次服用30毫克米安舍林后或连续使用米安舍林一周和两周后,血压控制均未观察到显著变化....
  • Human toxicity extract: /病例报告/ 一名50岁女性患者在给予单次治疗剂量的米安舍林后,出现了症状性窦性心动过缓的急性发作。心率通过注射阿托品得到纠正。再次给予米安舍林导致心动过缓复发。进一步检查显示无心脏异常。这是首例报道在接受治疗剂量米安舍林的患者中出现传导缺陷的病例。
  • non-human toxicity value: LD50 小鼠(雌性)静脉注射 31.0 mg/kg /米安色林盐酸盐/
  • Antidote and first aid: 高级治疗: 对于意识不清、严重肺水肿或呼吸停止的患者,考虑经口或经鼻气管插管进行气道控制。使用带阀面罩装置的正压通气技术可能有益。监测心律并按需治疗心律失常...。用D5W /SRP: "保持通畅",最小流速/开始静脉输液。如有低血容量迹象,使用乳酸盐林格氏液。注意液体过载迹象。考虑肺水肿的药物治疗...。对于有低血容量体征的低血压,谨慎给予液体。注意液体过载迹象...。用地西泮(Valium)治疗癫痫...。使用盐酸丙美卡因辅助眼睛冲洗...。/毒物A和B/
  • Effects During Pregnancy and Lactation: 在1999年至2008年对80,882对挪威母婴的研究中,392名女性报告了产后新使用抗抑郁药,201名报告她们在怀孕期间继续使用抗抑郁药。与未暴露对照组相比,怀孕晚期使用抗抑郁药与母乳喂养 initiation可能性降低7%相关,但对母乳喂养持续时间或 exclusivity 无影响。与未暴露对照组相比,新开始或重新使用抗抑郁药与6个月时主要母乳喂养可能性降低63%,以及任何母乳喂养可能性降低51%相关,同时母乳喂养突然停止的风险增加2.6倍。未提及特定的抗抑郁药。
Technical Documents
「No technical documents」
Related
「No upstream and downstream information yet」
Articles
「No related articles yet」
user reviews
Loading...
Consultation

Warm reminder:

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.!

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ,We will handle it for you as soon as possible, thank you for your support and trust.!

Research chemical 1mL

Research chemical 1mL; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1mL.

item number:96007a
Product model:1mL
level: 1mL
Lead Time:-
sold 636 Items
Ask Solution engineer
Qty

Recommended for you