
- Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
- exposure pathway: 胃肠道吸收良好。
- Toxicity summary: 氯苯那敏与组胺H1受体结合。这阻断了内源性组胺的作用,从而暂时缓解组胺引起的负面症状。
- Regulatory information: 新西兰化学品清单状态:氯苯那敏:没有单独批准,但可作为符合团体标准的产品中的成分使用。不允许以其自身化学品的形式使用。
- interaction: 与其他光敏药物同时使用/抗组胺药/可能导致光敏效应叠加。/抗组胺药/
- Toxicity Data: 口服LD50(大鼠):306 mg/kg 口服LD50(小鼠):130 mg/kg 口服LD50(豚鼠):198 mg/kg LD50:306 mg/kg(人类)(A308)
- Health Effects: 氯苯那敏具有血清素和去甲肾上腺素能作用。已被证明作为血清素-去甲肾上腺素再摄取抑制剂或SNRI起作用。[维基百科]
- Special Reports: DHHS/NTP; 氯苯那敏马来酸盐毒理学与致癌性研究在F344/N大鼠和B6C3F1小鼠中的技术报告系列第317号(1986) NIH出版物第86-2573号
- Non-human toxic extract: 马来酸氯苯那胺,一种组胺拮抗剂,在植入肿瘤后10天内口服给药给小鼠时,抑制了艾氏腹水癌的发展。
- Antidote and first aid: 抗组胺药物中毒没有特定疗法,治疗遵循一般症状性和支持性原则。...如果呼吸衰竭,机械通气支持比使用容易引发或加剧惊厥阶段的 analeptics 更安全、更有效地维持呼吸。/抗组胺药/
- Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
- Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
- Populations at Special Risk: 服用抗组胺药的老年患者可能更容易出现头晕、镇静、意识混乱和低血压。老年患者特别容易受到抗组胺药的抗胆碱副作用影响,如口干和尿潴留(尤其在男性中)。如果这些副作用发生并持续或严重,可能应停药。/抗组胺药/
- Effects During Pregnancy and Lactation: 有一些病例报告显示,男性长期使用抗组胺药会导致精子活力低下和受孕困难。这些影响在停药后消失。总的来说,父亲或精子捐献者接触的物质不太可能增加妊娠风险。更多信息,请参阅MotherToBaby信息表父亲暴露于https://mothertobaby.org/fact-sheets/paternal-exposures-pregnancy/。
- USGS Health-Based Screening Levels for Evaluating Water-Quality: 参考文献: Smith, C.D. and Nowell, L.H., 2024. 用于评估水质数据的基于健康的标准水平 (第 3 版)。DOI:10.5066/F71C1TWP
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Research chemical 1mL
Research chemical 1mL; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1mL.




