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Product introduction

AEE788(NVP-AEE 788)是高活性的EGFR和HER2/ErbB2抑制剂，IC50分别为2 nM和6 nM，对VEGFR2/KDR，c-Abl，c-Src和Flt-1抑制性较弱，对Ins-R，IGF-1R, PKCα and CDK1无抑制性。 AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1.

Specs ⸢ View details ⸥

Chinese name

AEE788 (NVP-AEE788),EGFR和VEGFR抑制剂, 血管内皮生长因子受体 1 抑制剂

English name

AEE788 (NVP-AEE788)

Chinese alias

English alias

CAS number

497839-62-0

molecular formula

C27H32N6

molecular weight

440.58 g/mol

Exact mass

≥97%

PSA

60.100 Å²

Logp

4.6

Technical Documents

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