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Product introduction

Information AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor ofFlt3with ki of 0.12 μM.Besides FLT3, AST487 also inhibitsRET,KDR,c-KIT,and c-ABL kinasewith IC50 values below 1 μM. Targets RET ; KDR ; c-Kit ; c-Abl ; FLT3 (Cell-free assay) ; ;; 0.12 μM(Ki)

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Chinese name

AST-487 (NVP-AST487), 酪氨酸蛋白激酶受体 RET 抑制剂

English name

AST-487 (NVP-AST487)

Chinese alias

English alias

NVP-AST487 | NVP-AST-487 | AC-5620 | W34UO2M4T6 | HY-15002 | ZB1589 | BDBM31085 | 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea | DTXSID70212239 | Q27074554 | HY-W009498 | 1-[4-[(4-eth

CAS number

630124-46-8

molecular formula

C26H30F3N7O2

molecular weight

529.56 g/mol

Exact mass

PSA

94.700 Å²

Logp

3.8

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