AM281 是一种选择性 CB1 受体拮抗剂，IC50 为 9.91 nM。AM281 抑制 CB2 受体，IC50 为 13000 nM。 AM281 is a selective CB1 receptor antagonist with an IC50 of 9.91 nM. AM281 inhibits CB2 receptor with an IC50 of 13000 nM。 Application： AM281 has been used as a cannabinoid 1 receptor antagonist: to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in mice to study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experiments to study its effect on scopolamine-induced memory deficit using object recognition paradigm to block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain