AZD4694 (NAV4694), a fluorinated β-amyloid (Aβ) plaque neuroimaging PET radioligand, shows high affinity for Aβ fibrils ( K d = 2.3 nM) In Vivo Administration of unlabeled AZD4694 to rat showed that it has a pharmacokinetic profile consistent with good PET radioligands, it quickly entered and rapidly cleared from normal rat brain tissue . AZD4694 (4 mL/kg; intravenous injection) inhibits [ 3 H]AZD2184 binding (1 nM) in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague–Dawley rats (275-300 g) Dosage: 4 mL/kg Administration: I.v. Result: Inhibited [ 3 H]AZD2184 binding in a concentration-dependent manner, with a Ki of 23.1 nM, in postmortem brain sections from AD patients. Form:Solid IC50& Target:Kd: 2.3 nM (Aβ)