蟾蜍灵（Bufalin）是一种C-24类固醇，在C-17处带有一个α-吡喃酮环。它存在于蟾蜍（Venenum Bufonis）的毒液腺和皮肤中。蟾蜍灵是强心类固醇，是蟾蜍的地高辛类成分。 应用： 蟾蜍灵已被用于： 测试其对核因子κB（NF-κB）细胞和肿瘤坏死因子-α（TNF-α）刺激的类风湿关节炎成纤维样滑膜细胞（RAFLS）的侵袭和激活的影响。 作为软骨细胞中的核受体共激活因子3（NCOA3）抑制剂。 用于测试其在对吉非替尼有抗药性的肺癌细胞（NCI-H460）中的抗转移作用。 Bufalin is a C-24 steroid with an α-pyrone ring positioned at C-17. It is present in the venom glands and skin of toad, Venenum Bufonis. Bufalin is a cardiotonic steroid and is digoxin-like component of Chan Su. Application： Bufalin has been used: To test its effect on invasion and activation of nuclear factor kappa- B (NF-κB) cells and tumor necrosis factor-α (TNF-α) stimulated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs). As a nuclear receptor coactivator 3 (NCOA3) inhibitor in chondrocytes. To test its anti-metastasis effect in lung cancer cells (NCI-H460) resistant to gefitinib.