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Product introduction

Ailanthone (AIL, Δ13-Dehydrochaparrinone) 是一种来自臭椿Ailanthus altissima的天然通过抗肝癌(HCC)成分，可通过降低 cyclins 和 CDKs 的表达、提高 p21 和 p27 的表达来诱导G0/G1期细胞周期阻滞。Ailanthone 可触发DNA损伤，其特征为 ATM/ATR 通路的激活。Ailanthone 可在Huh7细胞中诱导线粒体介导、涉及 PI3K/AKT 信号通路的细胞凋亡。Ailanthone 也是全长 Androgen Receptor (AR-FL)和组成型活性截断AR剪接变体(AR-Vs, AR1-651)的抑制剂，对应的IC50值分别为69 nM和309 nM。

Specs ⸢ View details ⸥

Chinese name

臭椿酮

English name

Ailanthone

Chinese alias

(1β,11β,12α)-11,20-环氧-1,11,12-三羟基吡啶3,13(21)-二烯-2,16-二酮 | 臭椿酮 | 臭椿苦酮

English alias

o13-Dehydrochaparrinoneo13-Dehydrochaparrinone | 2H-1,11c-(Epoxymethano)phenanthro(10,1-bc)pyran-5,10(3H,6ah)-dione, 1,3a,4,7,7a,11,11a,11b-octahydro-8,11a-beta-dimethyl-3-methylene-1-alpha,2-beta,11-beta-trihydroxy- | Ailanthone, >=98% (HPLC) | HY-N1943

CAS number

981-15-7

molecular formula

C20H24O7

molecular weight

376.4 g/mol

Exact mass

≥98%(HPLC)

PSA

113.000 Å²

Logp

-1.100

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Research chemical CAS 981-15-7 HPLC ≥98% 5mg

Name: Research chemical CAS 981-15-7 HPLC ≥98% 5mg
Brand: 源叶
SKU: B20197-5mg

Yuanye Research chemical CAS 981-15-7 HPLC ≥98% 5mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：B20197-5mg

Product model：5mg

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Research chemical CAS 981-15-7 HPLC ≥98% 5mg

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