金丝桃素二环己基铵盐是从贯叶连翘中分离得到的天然产物金丝桃素的二环己基铵盐制剂。金丝桃素抑制单胺类神经递质血清素、多巴胺、去甲肾上腺素和GABA的摄取。抑制血清素摄取的具体机制与高福林诱导的细胞内钠离子水平升高有关。AMPA诱导的电流被金丝桃素竞争性和不完全抑制，而NMDA受体激活的离子电导被完全和不竞争性抑制。金丝桃素具有神经保护作用，可诱导β-淀粉样蛋白聚集体解体，改善空间记忆，减少星形胶质细胞增生和小胶质细胞活化。诱导型一氧化氮合酶（iNOS）的作用受到金丝桃素的调控，表明通过抑制iNOS在mRNA Hyperforin dicyclohexylammonium salt is the dicyclohexylammonium salt preparation of the natural product Hyperforin isolated from|Hypericum perforatum|. Hyperforin inhibits the uptake of the monoamine neurotransmitters serotonin, dopamine, noradrenaline, and GABA. The specific mechanism of serotonin uptake inhibition is correlated with Hyperforin-induced elevation of intracellular Na|+|levels. AMPA induced currents were shown to be competitively and incompletely inhibited by Hyperforin, while NMDA receptor-activated ionic conductance was completely and uncompetitively inhibited. Hyperforin is described to present neuroprotective effects, demonstrating the induction of amyloid-beta aggregate disassembly, improvement of spatial memory, and decrease of astrogliosis and microglia activation. The action of inducible nitric oxide synthase (iNOS) was modulated by Hyperforin, demonstrating reduced NO production through suppression of iNOS on the mRNA and protein levels, further correlating to the neuroprotection generated by this compound. Hyperforin demonstrates selective activation of the transient receptor potential channel 6. Activation of the PXR (pregnane X receptor) by Hyperforin produces induction of cytochrome p450 3A4 monooxygenase expression, promoting oxidation metabolism activity of this enzyme. Hyperforin dicyclohexylammonium salt is an activator of TRPC6.