- exposure pathway： 非妊娠患者单次阴道应用tioconazole后全身吸收可忽略不计。
- Toxicity summary： Tioconazole与14-α脱甲基酶相互作用，这是一种将羊毛甾醇转化为麦角甾醇的细胞色素P-450酶，麦角甾醇是酵母膜的重要组成部分。通过这种方式，tioconazole抑制麦角甾醇合成，导致细胞通透性增加。Tioconazole还可能抑制内源性呼吸，与膜磷脂相互作用，抑制酵母向菌丝形态的转化和嘌呤的摄取，损害甘油三酯和/或磷脂的生物合成，并通过阻断称为Gardos通道的离子转运途径抑制钙和钾离子穿过细胞膜的运动。
- Symptoms and Signs： 过量症状包括红斑、刺痛、水疱、脱皮、水肿、瘙痒、荨麻疹、灼烧感和皮肤的一般刺激，以及痉挛。
- Hazard categories and classifications： 水生慢性1级(58%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响
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Research chemical CAS 65899-73-2 HPLC; ≥99%; 100mg
Research chemical CAS 65899-73-2 HPLC; ≥99%; 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: HPLC; ≥99%; 100mg.
