
- Treatment: 获取心电图并立即开始心脏监护。保护患者的气道,建立静脉通路并开始胃肠道去污染。至少需要六小时的观察,包括心脏监护和对中枢神经系统或呼吸抑制、低血压、心律失常和/或传导阻滞以及癫痫发作迹象的观察。如果在此期间任何时间出现毒性迹象,需要延长监护。(L1712)
- exposure pathway: 口服。快速吸收
- Toxicity summary: 三甲丙咪嗪的作用机制与其他三环类抗抑郁药不同。三甲丙咪嗪通过减少去甲肾上腺素和血清素(5-HT)的再摄取起作用。
- Regulatory information: 新西兰 EPA 化学品状态清单:三甲丙咪嗪:没有单独批准,但可作为受团体标准覆盖的产品中的成分使用。不允许以其自身形式作为化学品使用。
- Hepatotoxicity: 可能性评分: D(可能是临床上明显的肝损伤的罕见原因)。
- Symptoms and Signs: 副作用包括激动、昏迷、混乱、惊厥、瞳孔扩大、注意力不集中、嗜睡、幻觉、高烧、心率不齐、低体温、肌肉僵硬、反射亢进、严重低血压、木僵、呕吐
- Hazard categories and classifications: 水生慢性1(13%)
- Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
- Effects During Pregnancy and Lactation: 在1999年至2008年对80,882对挪威母婴的研究中,392名女性报告了产后新使用抗抑郁药,201名报告她们在怀孕期间继续使用抗抑郁药。与未暴露对照组相比,怀孕晚期使用抗抑郁药与母乳喂养 initiation可能性降低7%相关,但对母乳喂养持续时间或 exclusivity 无影响。与未暴露对照组相比,新开始或重新使用抗抑郁药与6个月时主要母乳喂养可能性降低63%,以及任何母乳喂养可能性降低51%相关,同时母乳喂养突然停止的风险增加2.6倍。未提及特定的抗抑郁药。
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Research chemical CAS 739-71-9 HPLC ≥98% 10mg
Yuanye Research chemical CAS 739-71-9 HPLC ≥98% 10mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.




