CDC25磷酸酶抑制剂I，BN82002是一种细胞可渗透的邻羟基苄氨基化合物，据报道它具有抗肿瘤特性。它已被证明可作为 CDC25 磷酸酶家族的有效、选择性和不可逆抑制剂（25A、25B2、25B3、25C 和 25C-cat 的 IC|50|= 2.4、3.9、6.3、5.4 和 4.6 μM，分别）。据报道，对 CDC25 磷酸酶的选择性比 CD45 酪氨酸磷酸酶高约 20 倍。还显示延迟细胞周期进程|体外|(IC|50|= ~7.2-32.6 μM)，并减少异种移植人胰腺细胞 MIA PaCa-2 (15 mg/kg, i.p. route) 的无胸腺小鼠的肿瘤生长. CDC25 Phosphatase Inhibitor I, BN82002, is a cell-permeable ortho-hydroxybenzylamino compound that has been reported to display antitumor properties. It has been shown to act as a potent, selective and irreversible inhibitor of the CDC25 phosphatase family (IC|50|= 2.4, 3.9, 6.3, 5.4, and 4.6 μM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Reported to display a ~20-fold greater selectivity for CDC25 phosphatases over CD45 tyrosine phosphatase. Also shown to delay cell cycle progression|in vitro|(IC|50|= ~7.2-32.6 μM), and reduces tumor growth in athymic mice xenografted with the human pancreatic cells MIA PaCa-2 (15 mg/kg, i.p. route).