已发现细胞渗透性抗生素香豆霉素A | 1 |是能够激活修饰的Raf-1蛋白并刺激丝裂原激活的蛋白激酶级联反应的二聚剂。还已经报道该化合物诱导GyrB-Janus激酶（JAK）2融合蛋白的自磷酸化，从而绕过受体活化。JAK是与细胞因子受体的胞内结构域相互作用的细胞质蛋白激酶，其在信号转导中起重要作用。JAK的活化被认为诱导细胞增殖。研究表明，香豆霉素A | 1 |可以通过与回旋酶B亚基结合来抑制回旋酶的超螺旋活性。 Coumermycin A|1|, a cell permeable antibiotic, has been found to be a dimerizing agent that can activate a modified Raf-1 protein and stimulate the mitogen-activated protein kinase cascade. This compound has also been reported to induce autophosphorylation of GyrB-Janus Kinase (JAK) 2 fusion proteins, thus bypassing receptor activation. JAKs are cytoplasmic protein kinases that interact with intracellular domains of cytokine receptors which plays an important role in signal transduction. The activation of JAK is thought to induce cell proliferation. Studies suggest that Coumermycin A|1|can inhibit the supercoiling activity of gyrase by binding to the gyrase B subunit.