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Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies sμggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile.An allosteric activator of CaSR Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies suggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile. An allosteric activator of CaSR

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Chinese name

盐酸西那卡塞, 钙传感受体正异位调节剂

English name

Cinacalcet HCl

Chinese alias

盐酸西那卡塞 | 盐酸甲状旁腺激素 | N-((1R)-1-(1-萘基)乙基)-3-(3-(三氟甲基)苯基)丙-1-胺盐酸盐

English alias

1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride | CAS-364782-34-3 | CINACALCET HYDROCHLORIDE [USP-RS] | MLS006010213 | Z1198150431 | DTXSID3046792 | NPS-1493 | CNC-HCl | N-((1R)-1-(1-naphthyl)ethyl)-3-(3-(t

CAS number

364782-34-3

molecular formula

C22H22F3N·HCl

molecular weight

393.87 g/mol

Exact mass

≥99%

PSA

12.000 Å²

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Technical Documents

364782-34-3 | Cinacalcet Hydrochloride.pdf
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