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有力地（低nM）增强了α4β3δ受体介导的GABA诱发的电流。它对由α4β32受体介导的GABA反应的影响很小。在相似的浓度下，DS1直接激活该受体，并且是已知最有效的α4β3δ受体激动剂。该化合物有机会成为δ-GABA| A |受体的激动剂金标准品。 Potently (low nM) enhances GABA-evoked currents mediated by α4β3δ receptors. It has little effect on GABA responses mediated by α4β3 2 receptors. At similar concentrations, DS1 directly activates this receptor and is the most potent known agonist of α4β3δ receptors. This compound has an opportunity to be become an agonist golden stardard for δ-GABA|A|receptors.

Specs ⸢ View details ⸥

Chinese name

DS1

English name

DS1

Chinese alias

English alias

CAS number

372497-52-4

molecular formula

C18H10Br2ClN3OS

molecular weight

511.62 g/mol

Exact mass

PSA

74.600 Å²

Logp

6.300

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