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Product introduction

25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.IC50 value:Target: VD metaboliteThe biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The \bone calcium mobilization\ of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3. Form:Solid IC50& Target:Human Endogenous Metabolite

Specs ⸢ View details ⸥

Chinese name

25,26-Dihydroxyvitamin D3

English name

25,26-Dihydroxyvitamin D3

Chinese alias

25,26-二羟基维生素 D3

English alias

(6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-1,2-diol | AKOS030526771 | 9,10-Secocholesta-5,7,10(19)-triene-3,25,26-triol, (3beta,5Z,7E)- | 25,26

CAS number

29261-12-9

molecular formula

C27H44O3

molecular weight

416.64 g/mol

Exact mass

≥98%

PSA

60.700 Å²

Logp

5.1

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