- Harmful effect： 在一项研究中，研究人员将总共 3,047 名男性随机分配到安慰剂组、多沙唑嗪组或与非那雄胺联合治疗组。与安慰剂组相比，服用多沙唑嗪和联合治疗的直立性低血压和头晕的不良反应发生率显著更高。据报道，不良反应率在平均 4.5 年的治疗期间于第一年达到峰值。
- Toxicity summary： 关于包括多沙唑嗪在内的 α-1 拮抗剂的过量使用和毒性的文献报道仍然非常有限。2005 年有一例急性多沙唑嗪过量的病例报告。研究发现，患者出现嗜睡、血压下降和反射性心动过速，但没有直立性低血压或其他异常。患者在 8 小时内通过支持治疗完全苏醒，并在进入急诊室后 48 小时出院。尽管关于多沙唑嗪毒性的文献有限，但它似乎具有低急性毒性。
- Regulatory information： REACH注册物质：状态：活跃 更新：2020-07-01 https://echa.europa.eu/registration-dossier/-/registered-dossier/31210
- Hepatotoxicity： 可能性评分：E*（尚未证实但怀疑是引起明显肝损伤的罕见原因）。
- Hazard categories and classifications： 水生慢性2级 (80%)
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： 截至修订日期，未在哺乳期妇女中找到相关已发表信息。然而，药理作用相似的药物哌唑嗪不影响高血压患者的血清催乳素浓度，表明多沙唑嗪可能不影响催乳素水平。已建立哺乳期的母亲的催乳素水平可能不会影响她的母乳喂养能力。
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Duo Sha Zuo Qin 10mM in DMSO 1ml
Duo Sha Zuo Qin 10mM in DMSO 1ml Macklin 74191-85-8, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.
