- Treatment： 如发生过量，应通过诱导呕吐或洗胃排空胃，并仔细观察患者给予对症和支持治疗。由于高度蛋白质结合，血液透析可能无效。(L1712)
- exposure pathway： 口服给药后迅速且完全吸收，生物利用度为80-90%。口服给药后2-3小时达到血浆峰浓度。
- Toxicity summary： 双氟尼沙的镇痛和抗炎作用的精确机制尚不清楚。双氟尼沙是前列腺素合成酶抑制剂。在动物中，前列腺素使传入神经敏感并增强缓激肽诱导疼痛的作用。由于已知前列腺素是疼痛和炎症的介质之一，双氟尼沙的作用模式可能是由于外周组织中前列腺素减少。
- Regulatory information： 加州化妆品安全计划(CSCP)报告成分：报告 - 无论成分在产品中的预期功能如何
- Toxicity Data： LD50: 392 mg/kg (口服, 大鼠) (A308) LD50: 439 mg/kg (口服, 小鼠) (A308) LD50: 603 mg/kg (口服, 兔子) (A308)
- Hepatotoxicity： 可能性评分：C（可能是明显肝损伤的原因）。
- Symptoms and Signs： 过量症状包括昏迷、心动过速、昏沉和呕吐。
- Other safety information： 化学品评估：IMAP评估 - [1,1'-联苯]-3-甲酸, 2',4'-二氟-4-羟基-：环境I级评估
- Hazard categories and classifications： 生殖毒性 2 (92.9%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响
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Research chemical CAS 22494-42-4 10mM 1ml
Research chemical CAS 22494-42-4 10mM 1ml, complete specifications, for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
