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Product introduction
D-环丝氨酸是一种具有R构型的4-氨基-1,2-噁唑烷-3-酮。它是由灰色链霉菌(Streptomyces garyphalus)或兰花链霉菌(S. orchidaceus)产生的抗生素,当对主要药物产生耐药性或毒性时,作为多药治疗方案的一部分用于治疗结核病。作为D-丙氨酸的类似物,它通过竞争性抑制L-丙氨酸消旋酶(将L-丙氨酸转化为D-丙氨酸)和D-丙氨酸-D-丙氨酸连接酶(将D-丙氨酸掺入肽聚糖形成和细菌细胞壁合成所需的五肽)来干扰细菌细胞壁的合成。它具有代谢物、抗结核药物、抗代谢物、抗感染剂和NMDA受体激动剂的作用。它...
Chinese name
<i>D</i>-环丝氨酸
English name
(4R)-4-amino-1,2-oxazolidin-3-one
Chinese alias
环丝氨酸,(R)-(+)-环丝氨酸 | D-4-氨基-3-异噁唑烷酮
English alias
D-cycloserine | cycloserine | 68-41-7 | Seromycin | orientomycin | Oxamycin | Cyclo-D-serine | Cyclorin | Cicloserina | Farmiserina | Miroseryn | Tisomycin | Wasserina | Closina | D-4-amino-3-isoxazolidinone | Cycloserinum | (+)-4-Amino-3-isoxazolidinone
CAS number
68-41-7
molecular formula
C3H6N2O2
molecular weight
102.09
Exact mass
-
PSA
64.4
Logp
-1.5
Safety
  • Storage conditions: 储存在40°C (104°F)以下,最好在15至30°C (59至86°F)之间,除非制造商另有说明。储存在密封容器中。
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • Regulatory information: 新西兰EPA化学品清单状态:3-异噁唑烷酮,4-氨基-,(4R)-:没有单独批准,但可在适当的团体标准下使用
  • interaction: 环丝氨酸可能通过作为吡哆素拮抗剂或增加吡哆素的肾排泄而导致贫血或周围神经炎;接受环丝氨酸的患者可能需要增加吡哆素的需求量。
  • Hepatotoxicity: 可能性评分:E*(尚未证实但可能是临床上明显的肝损伤的原因)。
  • Human toxicity extract: ... 除了嗜睡和精神错乱外,还引起模糊不清的视觉障碍。... 414名患者中有5人出现眼睛症状,包括闪烁感或压迫感... 在接受治疗的27名患者中,报告了一例视力闪烁和一例结膜炎。
  • Other safety information: 化学品评估:IMAP评估 - 3-异噁唑烷酮,4-氨基-,(R)-:人类健康I级评估
  • Hazard categories and classifications: STOT SE 3 (20%)
  • Non-human toxic extract: 环丝氨酸在Ames微生物致突变试验或非计划DNA修复试验中无致突变性。迄今为止尚未进行评估环丝氨酸致癌潜力的研究。
  • Antidote and first aid: 精神病发作...在2周内几乎总是可逆的,大剂量的氯丙嗪可能加速恢复。
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2016.02.015
  • Effects During Pregnancy and Lactation: 截至修订日期,未找到相关已发表信息。
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D-cyclo acid 98% 1/g

D-cyclo acid 98% 1/g 68-41-7, , .

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