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FBPase-1抑制剂是一种细胞可渗透的苯并恶唑磺酰胺化合物，可通过在AMP变构结合位点竞争来抑制hFBPase-1的酶活性。FBPase-1抑制剂已显示出可以在饥饿的大鼠肝癌细胞中阻断葡萄糖的产生。应用 FBPase-1抑制剂，通过在AMP变构结合位点竞争来抑制hFBPase-酶活性。FBPase-1抑制剂已被证明可阻断饥饿大鼠肝癌细胞中葡萄糖的产生。 FBPase-1 Inhibitor is a cell-permeable benzoxazolo-sulfonamide compound that inhibits hFBPase-1 enzymatic activity by competing at the AMP allosteric binding site. FBPase-1 Inhibitor has been shown to block glucose production in starved rat hepatoma cells.

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Chinese name

FBPase-1抑制剂

English name

FBPase-1 inhibitor

Chinese alias

2,5-二氯-N-(5-氯苯并[d]恶唑-2-基)苯磺酰胺

English alias

Fructose 1,6-bisphosphatase-1 Inhibitor

CAS number

883973-99-7

molecular formula

C13H7Cl3N2O3S

molecular weight

377.63 g/mol

Exact mass

≥97%

PSA

80.600 Å²

Logp

4.500

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