FIIN-2是一种不可逆的泛-FGFR抑制剂，对FGFR1/2/3/4的IC50分别为3.09 nM，4.3 nM，27 nM 和 45.3 nM。 Information FIIN-2 is an irreversible, pan-FGFRinhibitor withIC50of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM for FGFR1/2/3/4, respectively. Targets FGFR1 (Cell-free assay); FGFR2 (Cell-free assay); FGFR3 (Cell-free assay); FGFR4 (Cell-free assay) 3.09 nM; 4.3 nM ;27 nM; 45.3 nM In vitro In FGFR1-4 Ba/F3 cells, FIIN-2 inhibits cell proliferation with EC50 in the single- to double-digit nanomolar range. FIIN-2 also shows excellent antiproliferative activity in a variety of backgrounds, including cell lines that have gatekeeper mutations in FGFR1 and that are dependent on FGFR4. In vivo In a zebrafish developmental model, FIIN-2 causes mild or severe phenotypes to the tail morphogenesis by inhibiting FGFR. Cell Research(from reference) Cell lines：NCI-H2077, NCI-H1581, H520, Kato III, AN3CA, RT112, A2780, 4T1, and SKOV-3 cells Concentrations：1.0 μM Incubation Time：96 h