FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1) , used in the research of acute inflammatory diseases such as acute lung injury. In Vitro FTY720 (S)-Phosphate is an agonist of S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1, but shows no effect on inducing ubiquitination of S1PR1. FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI) and attenuates lung tissue leukocyte infiltration in bleomycin-injured mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:S1PR1