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Product introduction
Flavopiridol能与ATP竞争抑制CDK,对CDK1,CDK2,CDK4和CDK6的IC50为40 nM,同时对EGFR和PKA也有一定抑制性。A synthetic flavonoid derivative, potent inhibitor of CDKs. Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA A synthetic flavonoid derivative, potent inhibitor of CDKs.
Chinese name
夫拉平度, 细胞周期蛋白依赖性激酶 7 抑制剂
English name
Flavopiridol
Chinese alias
夫拉平度
English alias
L868275 | ALVOCIDIB [MART.] | AS-74761 | Q4063441 | 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one | 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methyl-4-piperidinyl)-, rel-(-)-
CAS number
146426-40-6
molecular formula
C21H20ClNO5
molecular weight
401.85 g/mol
Exact mass
-
PSA
90.200 Ų
Logp
3.3
Technical Documents
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≥99% 100/mg

≥99% 100/mg Macklin 146426-40-6, available in complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials

item number:F833151-100mg
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