FB23-2 是一种有效、选择性的 mRNA N⁶- 甲基腺嘌呤脱甲基酶 FTO 抑制剂 应用： FB23-2 具有抗增殖作用。 FB23-2 能用于急性髓系白血病 (AML) 的研究。 Information FB23-2 FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits FTO's N 6 -methyladenosine (m 6 A) demethylase activity with IC50 of 2.6 μM. Targets FTO (Cell-free assay) 2.6 μM In vitro FB23-2 directly binds to FTO and selectively inhibits FTO’s m 6 A demethylase activity. Mimicking FTO depletion, FB23-2 dramatically suppresses proliferation and promotes the differentiatiopoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells in vitro. In vivo FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice. Cell Research(from reference) Cell lines：Leukemia cells NB4, U937, MV4-11, ML-2; MONOMAC6 (ACC-124) cells; 293T cells; The mouse bone marrow cells FLT3ITD/NPM1, MA9 Concentrations：10 μM, 5 μM Incubation Time：24 h, 72 h