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Product introduction

Information GDC046 (Compound 3) is a potent, selective, and orally bioavailable inhibitor ofTYK2with Ki of 4.8 nM, 83.8 nM, 27.6 nM and 253 nM for TYK2, JAK1, JAK2, and JAK3, respectively. Targets TYK2 (Cell-free assay); JAK2 (Cell-free assay); JAK1 (Cell-free assay); JAK3 (Cell-free assay) 4.8 nM(Ki); 27.6 nM(Ki); 83.8 nM(Ki); 253 nM(Ki)

Specs ⸢ View details ⸥

Chinese name

GDC046

English name

GDC046

Chinese alias

English alias

Benzamide,2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-

CAS number

1258292-64-6

molecular formula

C16H13Cl2N3O2

molecular weight

350.2 g/mol

Exact mass

≥99%

PSA

71.100 Å²

Logp

2.900

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