- exposure pathway： 口服、皮肤接触、吸入和注射（受污染药物）。(A3101)
- Toxicity summary： Gliotoxin具有免疫抑制特性，因为它可能抑制并导致某些免疫系统的细胞凋亡，包括中性粒细胞、嗜酸性粒细胞、粒细胞、巨噬细胞和胸腺细胞。它还作为法尼基转移酶的抑制剂。Gliotoxin非竞争性地抑制20S蛋白酶体的胰凝乳蛋白酶样活性，并显示抗炎活性。它通过阻断细胞膜中的硫醇基团起作用。Gliotoxin还具有细胞毒性，可导致神经突退化。霉菌毒素通常能够通过人体有机阴离子转运蛋白(hOATs)和人体有机阳离子转运蛋白(hOCTs)进入肝脏和肾脏。它们还可以抑制这些转运蛋白对阴离子和阳离子的摄取，干扰内源性代谢物的分泌，d...
- Regulatory information： 新西兰EPA化学品清单状态：10H-3,10a-表硫代吡嗪并[1,2-a]吲哚-1,4-二酮，2,3,5a,6-四氢-6-羟基-3-(羟甲基)-2-甲基-，(3R,5aS,6S,10aR)-：没有单独批准，但可在适当的团体标准下使用
- Health Effects： Gliotoxin具有免疫抑制作用。它还具有细胞毒性，可导致神经突退化。(L1941, A2951)
- Hazard categories and classifications： 急性毒性 3 (100%)
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
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chemical 95% 5mg
chemical 95% 5mg CAS 67-99-2, complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
