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Product introduction

GDC-0068(RG 7440)是泛Akt抑制剂，对Akt1/2/3的IC50分别为5 nM/18 nM/8 nM，比对PKA的抑制性高620倍。 GDC-0068(RG 7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.

Specs ⸢ View details ⸥

Chinese name

GDC-0068,Akt1 / 2/3抑制剂, 丝氨酸/苏氨酸蛋白激酶 AKT 抑制剂

English name

GDC-0068

Chinese alias

帕他色替

English alias

RG7440 | GDC0068 | GDC 0068 | RG-7440 | RG 7440 | DTXSID9041152 | Ipatasertib; GDC-0068 | NCGC00182063-03 | AS-17027 | 0RF | IPATASERTIB [WHO-DD] | (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperaz

CAS number

1001264-89-6

molecular formula

C24H32ClN5O2

molecular weight

458 g/mol

Exact mass

PSA

81.600 Å²

Logp

2.5

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